The Arora Translational Lab is an invigorated endeavor of passionate physician-scientists in the Division of Cardiovascular Disease at UAB, to translate experimental knowledge and discoveries into an improved understanding of human physiology through clinically-focused patient-oriented research. The lab strives to advance research in the fields of cardiovascular physiology, pathology, epidemiology, biomarkers, risk-reduction, clinical outcomes and health disparities. The ongoing and completed clinical trials by the lab are aimed at elucidating the differences in cardiovascular physiology, mediated by the natriuretic peptide system, to advance the precision medicine approach of individualization of preventive and therapeutic strategies for common cardiovascular conditions. The prospective trials led by the lab are aimed at evaluating the improvement in cardiovascular health by physiological and pharmacological perturbations of the natriuretic peptide system. In a recently published clinical trial, the lab was able to highlight biological basis for key racial differences in the cardiometabolic physiology vis-à-vis the natriuretic peptide system. This work was built upon the prior work by the lab to understand the molecular mechanisms racial differences in natriuretic peptide levels and the impact of this commonly used biomarker on cardiovascular outcomes.
Our research group has successfully applied both population-based epidemiological approaches as well as patient based studies to examine a broad range of outcomes-related and physiological topics focusing on the link between natriuretic peptide system and cardiometabolic disease.